Sadabahar/Madagascar - Health benefits, application, chemical constituents, side effects and many more

 

 Sadabahar/Madagascar


Catharanthus roseus is commonly called as Periwinkle, Madagascar periwinkle, and Sadabahar. It grows throughout India and is found as an escape in waste places and sandy tracts. More than 130 different compounds have been reported including about 100 monoterpenoid indole alkaloids. As an important medical plant, it has a good antioxidant potential throughout its parts under drought stress. There are several health benefits of Catharanthus roseus leaves such as maintaining blood sugar, lowering high blood pressure, menstruation irregularities, Hodgkin's disease, and as antioxidant, antitumour, anti-mutagenic.

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It has different names in different languages such as Marathi name(Sadabahar, Sadaphool),  Hindi name (Sadab.............................read more



Phytochemical constituents

  • The principal alkaloids present in the aerial (nonfloral) parts are VBL (vincaleukoblastine, VLB), VCR (leurocristine, vincaleurocristine), vincarodine, vincoline, leurocolombine, viramidine, vincathicine, vincubine, isositsirikine, vincolidine, lochrovicine, catharanthine, vindoline, leurosine, lochnerine, tetrahydroalstonine, and vindolinine. Ajmalicine (raubasine), serpentine, and reserpine are the main alkaloids in the root while coronaridine, 11-methoxy tabersonine, tetrahydroalstonine, ajmalicine, vindorosidine, and vincristine dominate in the flower. 
  • More than 130 indole alkaloids, collectively termed terpenoid indole alkaloids (TIAs), have been extracted from periwinkle. Some of these alkaloid compounds have distinct medicinal properties. The alkaloid content is highest at the flowering stage.
  • However of the over hundred alkaloids discovered, only five consisting of vinblastine, vincristine, 3′,4′-anhydrovinblastine, serpentine, and ajmalicine are marketed.
  • Other Catharanthus species such as C. longifolius, C. trichophyllus, and C. lanceus are known to possess vindoline type alkaloids.
  • It produces a wide spectrum of phenolic compounds with radical scavenging ability, including C6C1 compounds such as 2,3-dihydroxybenzoic acid, as well as phenylpropanoids such as cin.............................read more




Properties and Benefits



Uses, Remedies, Benefits and Application 

1) Making a decoction by mixing evergreen root and Arjun bark in equal quantity, it is beneficial in heart block, hypertension, etc. This kwath also controls the amount of cholesterol in the blood.


2) For irregular menstruation : Leaf decoction in irregular menstruation:6 to 8 fresh leaves of the plant are boiled with 2 cup of water and reduced to half a cup. This is taken regularly for three consecutive menstrual cycles. This controls the heavy menstrual flow and regularizes scanty flow too. 


3) 250-500 mg of root powder is taken along with honey. This has potent effect in Urinary disorders.

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4) Sadabahar flower and pomegranate tender buds are taken and fresh juice is obtained. This is instilled to the nostrils in case of nasal bleeding. If it is retained in the mouth  bleeding gums, mouth ulcers and sore throats are also relieved. 

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5) Local application in Insect and wasp bites: Fresh juice/fine paste of the leaves if applied to the bite area of the insects and wasps. This reduces irritation and swelling. 


6) Fine paste of vinca, neem and turmeric in acne and related skin scars:Equal quantity of fresh leaves of vinca and neem and turmeric fresh rhizome are taken and fine paste is made. This is applied over the acne lesions and skin scars. Regular application gives excellent results in this condition.

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7) In India and other countries, it is commonly available varieties of Catharanthus (Sadabahar) are with red & white flowers  which are botanically identified as Lochnera rosea or Vinca rosea with red flower variety and Lochnera alba or Vinca alba with white  flower variety


8) In Madagascar, the bitter and astringent leaves have been applied as an emetic; roots have been used as a purgative, vermifuge, depurative, hemostatic agent and toothache remedy. In the Philippines, the leaf decoction is an herbal treatment for diabetes, young leaves are for stomach cramps, and root decoction is for intestinal parasitism. Maur.............................read more



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Refrence :

  1. ScientificWorldJournal. 2014; 2014: 304120.  PMCID: PMC3982472
  2. ScientificWorldJournal. 2015; 2015: 982412.  PMCID: PMC4312627
  3. Karnataka Medicinal Plants Volume - 2 
  4. J Clin Biochem Nutr. 2007 May; 40(3): 163–173.  PMCID: PMC2275761
  5. Local tradition and knowledge
  6. Journal of Ayurveda and Integrated Medical Sciences ; Vol. 6 No. 3 (2021): MAY-JUNE
  7. International Journal of Research in Pharmacy and Pharmaceutical Sciences. Volume 2; Issue 2; March 2017; Page No. 20-23. ISSN: 2455-698X; 
  8. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056.  Volume: 05 Issue: 06 | June-2018
  9. Int. J. Res. Ayurveda Pharm. 7(Suppl 3), Jul - Aug 2016
  10. NCBI
  11. PUBMED
  12. Basavarajeeyam
  13. Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423). Volume 3 Issue 10 October 2019
  14. Journal of Ethnopharmacology. Volume 284, 10 February 2022, 114647
  15. International Journal of Engineering Research & Technology (IJERT). Vol. 2 Issue 10, October - 2013
  16. World Journal of Pharmaceutical Research.  Volume 7, Issue 9, 1281-1289.
  17. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES.   Volume 5, Issue 9, 1987-1994
  18. Ayush Division , Head Quarters, Employeesʼ State insurance Corporation, New Delhi


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